Johnny Lyles, Jr., has performed with many notable recording artists. They include: Sam & Dave, James Brown, Chuck Jackson, Gary U.S. Bonds, Gene Chandler, Wilson Pickett, Jerry Butler, The Isley Brothers, Chuck Berry, Chubby Checker, The Platters, The Drifters, Little Anthony, The Imperials, Otis Redding, Aretha Franklin, George McCray, Bobby Womack, Sammy Davis, Jr., Frank Sinatra Jr., Paul Anka, Dion, Jimmy Bo Horn, Frankie Limeman and the Teenager, Little Willie John, The Coasters,